Insulin-like growth factors: the unrecognised oncogenes
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چکیده
منابع مشابه
Insulin, insulin-like growth factors and neoplasia.
Over the past decade, dozens of epidemiological studies and laboratory experiments have provided evidence for relationships between insulin-like growth factor (IGF) physiology and neoplasia. Population studies provide evidence for a modestly increased risk of a subsequent cancer diagnosis in subjects with IGF-I levels at the high end of the broad normal range, as compared to those at the low en...
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An accumulating body of epidemiologic and laboratory evidence suggests that insulin and insulin-like growth factors influence both the risk and the prognosis of cancer. In this brief review, I highlight topics covered in my lecture on research directions in this field, including the view that metformin deserves investigation as a potential adjunct in the treatment or prevention of cancer in per...
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GH and IGF-I are important regulators of bone homeostasis and are central to the achievement of normal longitudinal bone growth and bone mass. Although GH may act directly on skeletal cells, most of its effects are mediated by IGF-I, which is present in the systemic circulation and is synthesized by peripheral tissues. The availability of IGF-I is regulated by IGF binding proteins. IGF-I enhanc...
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© 1999 Journals of Reproduction and Fertility 1359-6004/99 $15.00 The insulin-like growth factors, IGF-I and IGF-II, have effects on metabolism, growth, proliferation and differentiation in many tissues and cell types (Jones and Clemmons, 1995) and are therefore important modulators of many aspects of physiology. Insulin-like growth factor actions are largely mediated via the type 1 IGF recepto...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1995
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1995.465